Smallpox, HIV: Oil-based Nasal Vaccine Technique Produces Immunity

Science Daily - Thursday February 28, 2008
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ScienceDaily (Feb. 28, 2008) A novel technique for vaccinating against a variety of infectious diseases -- using an oil-based emulsion placed in the nose, rather than needles -- has proved able to produce a strong immune response against smallpox and HIV in two new studies.

The results build on previous success in animal studies with a nasal nanoemulsion vaccine for influenza, reported by University of Michigan researchers in 2003.

Nanoemulsion vaccines developed at the Michigan Nanotechnology Institute for Medicine and the Biological Sciences at U-M are based on a mixture of soybean oil, alcohol, water and detergents emulsified into ultra-small particles smaller than 400 nanometers wide, or 1/200th the width of a human hair. These are combined with part or all of the disease-causing microbe to trigger the body's immune response

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